Study of self-consumption and net metering photovoltaic system

In Spain, regulations for Self-Consumption installations have been recently approved. However, regulations for Net Metering installations are still under discussion. The target of this study is to discuss different options for Net Metering implementation which are not defined yet. Also, an approach to new criteria for sizing this kind of installations will be done from different points of view: technical and economic. Different cases have been studied: the regulatory frame which was drafted by the former government (but not approved yet) and other proposals amending the mentioned draft that are being issued by other entities as National Energy Commission of Spain, Photovoltaic Producers Association, etc. The results let us conclude that the regulations which are drafted now will not permit the optimal performance of Net Metering installations neither from energy point of view nor economic point of view. It should be necessary to change the regulation draft just to reach the optimal performance of Net Metering installations.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

New challenges in microalgae biotechnology

Photosynthetic protists, also called microalgae, have been systematically studied for more than a century. However, only recently broad biotechnological applications have fostered a novel wave of research on their potentialities as sustainable resources of renewable energy as well as valuable industrial and agro-food products. At the recent VII European Congress of Protistology held in Seville, three outstanding examples of different research strategies on microalgae with biotechnological implications were presented, which suggested that integrative approaches will produce very significant advances in this field in the next future. In any case, intense research and the application of systems biology and genetic engineering techniques are absolutely essential to reach the full potential of microalgae as cell-factories of bio-based products and, therefore, could contribute significantly to solve the problems of biosustainability and energy shortage

Estación de trabajo para registro 3D y fusión de imágenes para la planificación de radioterapia

Este trabajo presenta una estación de trabajo para registro tridimensional y fusión de imágenes orientada a la ayuda en la planificación y monitorización de terapias de radiación externa. El concepto de radioterapia adaptativa propone la realización de una planificación del tratamiento en cada una de las sesiones a las que acude el paciente, lo que supondría un decremento importante en la radiación que afecta a los tejidos sanos circundantes al tumor y por tanto, una mejora significativa en la evolución de estos pacientes. Para reducir el tiempo que conlleva la delineación manual de los volúmenes de interés en la realización de una nueva planificación en cada sesión, la herramienta en la que se debe basar la radioterapia adaptativa es el registro tridimensional deformable de estudios CT para radioterapia. El prototipo que se presenta en este artículo permite el registro de imágenes DICOM mediante algoritmos no rígidos, su visualización, la comparación cualitativa de los resultados mediante fusión de imágenes, selección de regiones de interés en las imágenes y el almacenamiento de resultados en formato DICOM, visualizables por cualquier otro lector. El empleo de esta estación de trabajo, en combinación con algoritmos de reconstrucción tridimensional y segmentación automática desarrollados dentro del grupo, supone una gran ayuda en los procesos previos de la planificación radioterápica

Profiled support vector machines for antisense oligonucleotide efficacy prediction

BACKGROUND: This paper presents the use of Support Vector Machines (SVMs) for prediction and analysis of antisense oligonucleotide (AO) efficacy. The collected database comprises 315 AO molecules including 68 features each, inducing a problem well-suited to SVMs. The task of feature selection is crucial given the presence of noisy or redundant features, and the well-known problem of the curse of dimensionality. We propose a two-stage strategy to develop an optimal model: (1) feature selection using correlation analysis, mutual information, and SVM-based recursive feature elimination (SVM-RFE), and (2) AO prediction using standard and profiled SVM formulations. A profiled SVM gives different weights to different parts of the training data to focus the training on the most important regions. RESULTS: In the first stage, the SVM-RFE technique was most efficient and robust in the presence of low number of samples and high input space dimension. This method yielded an optimal subset of 14 representative features, which were all related to energy and sequence motifs. The second stage evaluated the performance of the predictors (overall correlation coefficient between observed and predicted efficacy, r; mean error, ME; and root-mean-square-error, RMSE) using 8-fold and minus-one-RNA cross-validation methods. The profiled SVM produced the best results (r = 0.44, ME = 0.022, and RMSE= 0.278) and predicted high (>75% inhibition of gene expression) and low efficacy (<25%) AOs with a success rate of 83.3% and 82.9%, respectively, which is better than by previous approaches. A web server for AO prediction is available online at . CONCLUSIONS: The SVM approach is well suited to the AO prediction problem, and yields a prediction accuracy superior to previous methods. The profiled SVM was found to perform better than the standard SVM, suggesting that it could lead to improvements in other prediction problems as well

Pre-treatment with grape seed extract reduces inflammatory response and oxidative stress induced by helicobacter pylori infection in human gastric epithelial cells

Helicobacter pylori (H. pylori) is a pathogenic bacteria identified as a potential risk factor for gastritis, gastric ulcers and gastric cancer. During the stomach colonization, H. pylori triggers a strong inflammatory response and subsequent oxidative stress, which are associated with tissue damage. For this reason, it is of particular interest to develop alternative natural tools that enable modulation of the associated damaging immune response. With this purpose, we obtained grape seed extract (GSE) from sweet (not fermented) food grade seeds. The aim of our study was to investigate the effect of GSE and its two enriched procyanidins fractions (OPC and PPC) on the inflammatory process and oxidative stress produced by different H. pylori strains in human gastric epithelial cells (AGS). Anti-inflammatory activity was evaluated by measuring the level of interleukin-8 (IL-8) secretion. IL-8 production was significantly reduced in H. pylori-infected human gastric epithelial cells pretreated with GSE or its enriched fractions when compared with non-pre-treated infected cells (from 21.6% to 87.8%). Pre-treatment with GSE or its fractions significantly decreased intracellular reactive oxygen species (ROS) production in AGS cells after infection, depending on the H. pylori strain. Our results also showed that GSE and its fractions demonstrate antibacterial activity against all strains of H. pylori used in the study. This work demonstrates the effectiveness of GSE enriched in procyanidins against the main events associated with H. pylori infection

Productive performance, carcass and meat quality of intact and castrated gilts slaughtered at 106 or 122 kg BW

A total of 200 (Landrace3Large White dam3Pietrain3Large White sire) gilts of 5063 days of age (23.361.47 kg BW) were used to investigate the effects of castration (intact gilt, IG v. castrated gilt, CG) and slaughter weight (SW; 106 v. 122 kg BW) on productive performance, carcass and meat quality. Four treatments were arranged factorially and five replicates of 10 pigs each per treatment. Half of the gilts were ovariectomized at 58 days of age (8 days after the beginning of the trial at 29.861.64 kg BW), whereas the other half remained intact. The pigs were slaughtered at 106 or 122 kg BW. Meat samples were taken at Musculus longissimus thoracis at the level of the last rib and subcutaneous fat samples were taken at the tail insertion. For the entire experimental period, CG had higher ( P,0.05) BW gain and higher ( P,0.001) backfat and Musculus gluteus medius fat thickness than IG. However, IG had higher ( P,0.05) loin and trimmed primal cut yields than CG. Meat quality was similar for IG and CG but the proportion of linoleic acid in subcutaneous fat was higher ( P,0.001) for IG. Pigs slaughtered at 122 kg BW had higher ( P,0.001) feed intake and poorer feed efficiency than pigs slaughtered at 106 kg BW. An increase in SW improved ( P,0.001) carcass yield but decreased ( P,0.05) trimmed primal cut yield. Meat from pigs slaughtered at the heavier BW was redder (a*; P,0.001) and had more ( P,0.01) intramuscular fat and less thawing ( P,0.05) and cooking ( P,0.10) loss than meat from pigs slaughtered at the lighter BW. In addition, pigs slaughtered at 122 kg BW had less ( P,0.01) linoleic acid content in subcutaneous fat than pigs slaughtered at 106 kg BW. Castration of gilts and slaughtering at heavier BW are useful practices for the production of heavy pigs destined to the dry-cured industry in which a certain amount of fat in the carcass is required. In contrast, when the carcasses are destined to fresh meat production, IG slaughtered at 106 kg BW is a more efficient alternative

Gene expression analyses determine two different subpopulations in KIT-negative GIST-like (KNGL) patients

Introduction: There are limited findings available on KIT-negative GIST-like (KNGL) population. Also, KIT expression may be post-transcriptionally regulated by miRNA221 and miRNA222. Hence, the aim of this study is to characterize KNGL population, by differential gene expression, and to analyze miRNA221/222 expression and their prognostic value in KNGL patients. Methods: KIT, PDGFRA, DOG1, IGF1R, MIR221 and MIR222 expression levels were determined by qRT-PCR. We also analyzed KIT and PDGFRA mutations, DOG1 expression, by immunohistochemistry, along with clinical and pathological data. Disease-free survival (DFS) and overall survival (OS) differences were calculated using Log-rank test. Results: Hierarchical cluster analyses from gene expression data identified two groups: group I had KIT, DOG1 and PDGFRA overexpression and IGF1R underexpression and group II had overexpression of IGF1R and low expression of KIT, DOG1 and PDGFRA. Group II had a significant worse OS (p = 0.013) in all the series, and showed a tendency for worse OS (p = 0.11), when analyzed only the localized cases. MiRNA222 expression was significantly lower in a control subset of KIT-positive GIST (p < 0.001). OS was significantly worse in KNGL cases with higher expression of MIR221 (p = 0.028) or MIR222 (p = 0.014). Conclusions: We identified two distinct KNGL subsets, with a different prognostic value. Increased levels of miRNA221/222, which are associated with worse OS, could explain the absence of KIT protein expression of most KNGL tumors

Predicting Acorn-Grass Weight Gain Index using non-destructive Near Infrared Spectroscopy in order to classify Iberian pig carcasses according to feeding regime

The classification of Iberian pig carcasses into different commercial categories according to feeding regime was evaluated by means of a non-destructive analysis of the subcutaneous adipose tissue using Near Infrared Spectroscopy (NIRS). A quantitative approach was used to predict the Acorn-Grass Weight Gain Index (AGWGI), and a set of criteria was established for commercial classification purposes. A total of 719 animals belonging to various batches, reflecting a wide range of feeding regimes, production systems and years, were analyzed with a view to developing and evaluating quantitative NIRS models. Results for the external validation of these models indicate that NIRS made clear differentiation of batches as a function of three feeding regimes possible with high accuracy (<i>Acorn, Recebo</i> and <i>Feed</i>), on the basis of the mean representative spectra of each batch. Moreover, individual analysis of the animals showed a broad consensus between field inspection information and the classification based on the AGWGI NIRS prediction, especially for extreme categories (<i>Acorn</i> and <i>Feed</i>).<br><br>La clasificación en distintas categorías comerciales según régimen alimenticio de canales de cerdo Ibérico fue evaluada mediante el análisis no destructivo de muestras de tejido adiposo subcutáneo por Espectroscopía del Infrarrojo Cercano (NIRS). Partiendo de una aproximación cuantitativa para predecir el Índice de Reposición en Montanera (IRM) se establecieron una serie de criterios para proceder a su clasificación comercial. Se analizaron un total de 719 animales pertenecientes a diversas partidas, que recogen una amplia variabilidad de muestras de distintos regímenes alimenticios, campañas y sistemas productivos, para el desarrollo y evaluación de los modelos NIRS cuantitativos. Los resultados de validación externa de los modelos indicaron que es posible discriminar con una gran exactitud entre partidas de distintos categorías (<i>Bellota, Recebo</i> y <i>Cebo</i>), en base al espectro medio representativo de cada partida. Además, el análisis individualizado de los animales mostró un amplio consenso entre la información recibida de campo y la clasificación en base a la predicción del parámetro IRM por NIRS, sobre todo para categorías con características extremas (<i>Bellota</i> y <i>Cebo</i>)

Manejo de la hemorragia subaracnoidea en pacientes ingresados en el área de Neurocirugía del hospital “Dr. Teodoro Maldonado Carbo”, 01 de enero al 31 de julio de 2002

Estudio realizado en el servicio de Neurocirugía del hospital “Dr. Teodoro Maldonado Carbo” durante 1 enero-31 julio 2002. Fueron 118 pacientes ingresados de los cuales se tomaron 16 pacientes que cumplieron con los criterios de inclusión y que por tanto se constituye en universo.Tipo de estudio: retrospectivo, descriptivo.Objetivos. General:Determinar cómo se realiza el manejo de los pacientes con hemorragia subaracnoidea ingresados en el servicio de Neurocirugía.Específicos:1.- Establecer por medio de porcentajes la morbimortalidad de los pacientes que cursan con Hemorragia Subaracnoidea.2.- Determinar la influencia que ejercen los antecedentes personales y hábitos de este grupo de pacientes.Resultados: De los 16 pacientes la patología determinada se presentó el 49% en mayores de 60 años; prevaleciendo también en el sexo masculino que alcanzó el 62%. En cuanto a los pacientes con antecedentes de hipertensión arterial se destacó el 25%, aún en aquellos individuos que seguían un tratamiento adecuado. En cuanto a la etiología se destacó el trauma cráneo encefálico con un 44%, seguido de los aneurismas con un 25%. Como medio de diagnóstico, la tomografía axial computarizada, con el 81%, demostró que sigue siendo el de primera elección. El tratamiento conservador alcanzó el 75% y en nuestro universo de estudio se obtuvo 62% de mejoría y 38% curación al momento del alta hospitalaria.Conclusiones: Se logró demostrar con este estudio el adecuado y eficaz manejo intra hospitalario para con este grupo de pacientes, no sólo con el hecho del alto porcentaje en el tratamiento conservador sino también porque no existió ningún paciente fallecido en nuestro universo de estudio

Ibero-American Society of Interventionism (SIDI) and the Spanish Society of Vascular and Interventional Radiology (SERVEI) Standard of Practice (SOP) for the management of inferior Vena Cava filters in the treatment of acute venous Thromboembolism

Objectives: to present an interventional radiology standard of practice on the use of inferior vena cava filters (IVCFs) in patients with or at risk to develop venous thromboembolism (VTE) from the Iberoamerican Interventional Society (SIDI) and Spanish Vascular and Interventional Radiology Society (SERVEI). Methods: a group of twenty-two interventional radiologist experts, from the SIDI and SERVEI societies, attended online meetings to develop a current clinical practice guideline on the proper indication for the placement and retrieval of IVCFs. A broad review was undertaken to determine the participation of interventional radiologists in the current guidelines and a consensus on inferior vena cava filters. Twenty-two experts from both societies worked on a common draft and received a questionnaire where they had to assess, for IVCF placement, the absolute, relative, and prophylactic indications. The experts voted on the different indications and reasoned their decision. Results: a total of two-hundred-thirty-three articles were reviewed. Interventional radiologists participated in the development of just two of the eight guidelines. The threshold for inclusion was 100% agreement. Three absolute and four relative indications for the IVCF placement were identified. No indications for the prophylactic filter placement reached the threshold. Conclusion: interventional radiologists are highly involved in the management of IVCFs but have limited participation in the development of multidisciplinary clinical practice guidelines